Shigeki Higashiyama Selected Research

Colorectal Neoplasms (Colorectal Cancer)

1/2022	Inactivation of axon guidance molecule netrin-1 in human colorectal cancer by an epigenetic mechanism.
1/2019	SNX9 determines the surface levels of integrin β1 in vascular endothelial cells: Implication in poor prognosis of human colorectal cancers overexpressing SNX9.
1/2013	Telmisartan inhibits cell proliferation by blocking nuclear translocation of ProHB-EGF C-terminal fragment in colon cancer cells.

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Shigeki Higashiyama Research Topics

Disease

37	Neoplasms (Cancer) 12/2021 - 04/2002
6	Prostatic Neoplasms (Prostate Cancer) 12/2021 - 11/2003
6	Neoplasm Metastasis (Metastasis) 10/2018 - 09/2002
6	Leukemia 11/2017 - 11/2003
6	Wounds and Injuries (Trauma) 04/2013 - 11/2003
6	Stomach Neoplasms (Stomach Cancer) 05/2012 - 04/2002
5	Cardiomegaly (Heart Hypertrophy) 11/2006 - 01/2002
4	Carcinogenesis 01/2022 - 04/2002
4	Breast Neoplasms (Breast Cancer) 01/2021 - 09/2004
4	Inflammation (Inflammations) 01/2019 - 04/2012
3	Colorectal Neoplasms (Colorectal Cancer) 01/2022 - 01/2013
3	Fibrosis (Cirrhosis) 01/2021 - 01/2012
3	Pathologic Processes 12/2020 - 01/2013
3	Urinary Bladder Neoplasms (Bladder Cancer) 03/2014 - 08/2004
3	Carcinoma (Carcinomatosis) 10/2013 - 03/2005
3	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 07/2013 - 06/2004
3	Colonic Neoplasms (Colon Cancer) 01/2013 - 03/2005
2	Macular Degeneration (Age-Related Maculopathy) 12/2020 - 01/2018
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 12/2020 - 07/2018
2	Type 2 Diabetes Mellitus (MODY) 12/2020 - 12/2005
2	Lung Injury 01/2017 - 01/2014
2	Ischemia 10/2010 - 05/2008
2	Lung Neoplasms (Lung Cancer) 04/2010 - 06/2004
2	Infections 12/2009 - 07/2005
2	Adenocarcinoma 09/2009 - 01/2001
2	Heart Diseases (Heart Disease) 02/2008 - 08/2005
1	Tissue Adhesions 01/2021
1	Necrosis 01/2021
1	Pheochromocytoma 12/2020
1	Metabolic Diseases (Metabolic Disease) 01/2020
1	Genomic Instability 01/2020
1	Hepatocellular Carcinoma (Hepatoma) 01/2019
1	Arthritis (Polyarthritis) 01/2019

Drug/Important Bio-Agent (IBA)

27	Heparin-binding EGF-like Growth Factor (HB-EGF)IBA 01/2018 - 01/2001
20	Epidermal Growth Factor (EGF)IBA 02/2019 - 01/2001
17	ErbB Receptors (EGF Receptor)IBA 01/2021 - 01/2002
13	Proteins (Proteins, Gene)FDA Link 01/2022 - 04/2002
13	Metalloproteases (Metalloproteinases)IBA 01/2021 - 01/2002
10	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 09/2014 - 01/2001
9	LigandsIBA 04/2013 - 03/2004
8	DisintegrinsIBA 01/2021 - 06/2004
7	Messenger RNA (mRNA)IBA 02/2019 - 04/2002
6	Heparin (Liquaemin)FDA LinkGeneric 04/2013 - 01/2001
5	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 12/2020 - 08/2004
4	CytokinesIBA 01/2021 - 08/2004
4	UbiquitinIBA 01/2021 - 01/2019
4	Promyelocytic Leukemia Zinc Finger ProteinIBA 01/2013 - 07/2006
3	CollagenIBA 12/2021 - 01/2013
3	Ligases (Synthetase)IBA 01/2021 - 01/2019
3	Biological ProductsIBA 12/2020 - 04/2012
3	AmphiregulinIBA 09/2014 - 04/2012
3	Cisplatin (Platino)FDA LinkGeneric 03/2014 - 06/2012
3	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 03/2005 - 01/2002
2	Netrin-1IBA 01/2022 - 01/2018
2	Glucagon-Like Peptide 1 (GLP 1)IBA 12/2020 - 07/2018
2	Pharmaceutical PreparationsIBA 12/2020 - 07/2013
2	DNA (Deoxyribonucleic Acid)IBA 01/2020 - 11/2005
2	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 02/2019 - 01/2019
2	Cullin Proteins (Cullins)IBA 02/2019 - 01/2019
2	IntegrinsIBA 01/2019 - 01/2012
2	Chemotactic FactorsIBA 01/2018 - 10/2013
2	EnzymesIBA 01/2018 - 09/2014
2	Transforming Growth Factors (Transforming Growth Factor)IBA 11/2017 - 09/2014
2	Gefitinib (Iressa)FDA Link 07/2013 - 12/2011
2	ThymidineIBA 01/2013 - 11/2005
2	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 10/2010 - 05/2008
2	AntibodiesIBA 04/2010 - 11/2002
2	Cadherins (E-Cadherin)IBA 12/2009 - 02/2006
2	Interleukin-8 (Interleukin 8)IBA 03/2005 - 08/2004
2	KB R7785IBA 05/2003 - 01/2002
1	Netrin ReceptorsIBA 01/2022
1	Conditioned Culture MediaIBA 12/2021
1	GelsIBA 12/2021
1	gallium 68 PSMA-11IBA 12/2021
1	AntigensIBA 12/2021
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2021
1	Monomeric GTP-Binding ProteinsIBA 01/2021
1	RNA (Ribonucleic Acid)IBA 01/2021
1	Matrix Metalloproteinases (MMPs)IBA 01/2021
1	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 12/2020
1	Dactinomycin (Actinomycin)FDA LinkGeneric 12/2020
1	TeaIBA 12/2020
1	Angiogenesis InhibitorsIBA 12/2020
1	Androgen Receptors (Androgen Receptor)IBA 01/2020
1	human ERBB2 proteinIBA 02/2019
1	Deubiquitinating EnzymesIBA 01/2019
1	PolyubiquitinIBA 01/2019
1	Lysine (L-Lysine)FDA Link 01/2019
1	Interleukin-6 (Interleukin 6)IBA 01/2019
1	Deubiquitinating Enzyme CYLDIBA 01/2019
1	epithelial membrane protein-1IBA 10/2018
1	copine IIIIBA 10/2018
1	Alcian BlueIBA 08/2018
1	IncretinsIBA 07/2018
1	neogeninIBA 01/2018

Therapy/Procedure

7	Therapeutics 10/2018 - 01/2002
3	Ligation 01/2017 - 07/2013
3	Drug Therapy (Chemotherapy) 07/2013 - 04/2012
1	Castration 12/2021
1	Lasers (Laser) 01/2018